Microbiological assay of bleomycin: Inactivation, tissue distribution, and clearance
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منابع مشابه
Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice.
A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.
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A sensitive, precise microbiological assay has been developed for the determination of tissue distribution of 5-diazouracil, a potential antitumor and antimicrobial agent.
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A bleomycin mixture which contained A2 as the main component and B2 as the second component was tritiated. The 3H-bleomycin thus prepared was subcutaneously injected to mice and the distribution of the bleomycin among organs of mice was determined. The results indicated a high concentration in skin and peritoneum. The concentrations determined by radioactivity were higher than those determined ...
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was precipitated (Kane et al., 1975) with 1,1,3,3-tetramethylurea, extracted with chloroform/methanol (1 : 1, v/v), washed with ether, and dried under N2. Amino acid analysis of this protein corresponded to that of apolipoprotein B, as did its electrophoretic mobility on urea/polyacrylamide-gel electrophoresis. Its specific radioactivity was obtained by radioactivity counting and protein determ...
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Chartreusin was produced in the fermentation liquors of Streptomyces chartreusis at peak concentrations of 200 to 300 mug/ml. The titers could be increased by 200 to 300% or more by incorporating d-fucose, a part of the chartreusin molecule, into the fermentation media. A microbiological assay with Sarcina lutea could detect concentrations of the drug of 0.5 to 1.0 mug/ml.
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ژورنال
عنوان ژورنال: Cancer
سال: 1974
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197405)33:5<1230::aid-cncr2820330507>3.0.co;2-c